Can Ozempic and Other GLP-1 Drugs Cause Suicidal Thoughts?

A man looking out a window.
Ozempic and other GLP-1 drugs are currently under safety review in several countries after a small number of cases have reported an increase in suicidal thoughts while taking the medications. CreativaImages/Getty Images
  • GLP-1 drugs like Ozempic, Wegovy, and Trulicty are currently under safety review following reports that these medications may increase the risk of suicidal thoughts.
  • The risk of suicidal thoughts is not currently listed as a potential side effect of these medications.
  • However, despite a relatively small number of cases reporting suicidal thoughts and self-harming behavior in people using GLP-1 medications, there has been no evidence of a direct cause.

Semaglutide (sold under the brand names Ozempic and Wegovy) as well as other GLP-1 medications that can aid with weight loss are currently under safety review for the potential risk of increasing suicidal thoughts

Following a relatively small number of cases reporting suicidal thoughts and self-harming behavior in people using GLP-1 receptor agonists, agencies in Canada, Europe, and the United Kingdom are assessing whether the side effect is caused by the medication or is associated with underlying conditions.  

Suicidal thoughts are not currently listed as a potential side effect of Ozempic, according to the U.S. Food and Drug Administration’s drug label and the EU product information. 

Along with Ozempic and Wegovy, here are some other GLP-1 drugs currently under review:

  • AstraZeneca’s medication exenatide (Bydureon)
  •  Eli Lilly’s dulaglutide (Trulicity)
  •  Sanofi’s lixisenatide
  • Sanofi’s Soliqua 

“GLP-1 receptor agonists have been used to treat type 2 diabetes for more than 15 years and for treatment of obesity for 8 years, including Novo Nordisk products such as semaglutide and liraglutide that have been on the market for more than 10 years,” Novo Nordisk, Ozempic’s manufacturer, said in a statement. Semaglutide is the active medical ingredient in Ozempic. 

“The safety data collected from large clinical trial programs and post-marketing surveillance have not demonstrated a causal association between semaglutide or liraglutide and suicidal and self-harming thoughts,” the company said. 

The use of Ozempic and other GLP-1 drugs have not been directly linked with suicidal thoughts or self-harm

“At this time, GLP-1 drugs like Ozempic have not been directly linked or even evaluated for a potential link to suicidal ideations,” says Dr. Mirela Loftus, PhD, medical director for Newport Healthcare. 

“There has been no causal effect documented in any literature,” says Dr. Steven Batash, FACG, a gastroenterologist currently affiliated with NYU Medical Center, Lenox Hill Hospital, and NewYork-Presbyterian Hospital to Healthline. Batash provides endoscopic weight loss procedures or non-surgical weight loss.

He adds that in his practice, he hasn’t come across anyone experiencing suicidal thoughts after taking a GLP-1 receptor agonist.

“The manufacturers deny that suicidal thoughts were reported during their trials,” says Dr. Jodie Pepin, clinical pharmacy program director at Harbor Health and an assistant professor of pharmacy at the University of Texas in Austin.

“As far as the newly reported suicidal thoughts possibly related to the GLP-1s, there will have to be an abundance of evidence that proves causation, not just correlation,” she says. 

Pepin also explains that millions of people have taken these medications, and the more people who take them, the more likely these side effects will show up.

“The numbers of suicidal thoughts are relatively small compared to the number of prescriptions written for these medications,” she adds. 

“The population who takes these medications have comorbidities or underlying conditions that may influence their response to drugs,” she tells Healthline. 

Examples include pre-existing mental health conditions like depression or comorbidities like heart disease, which can often be associated with depression, she adds.  

“These responses may have little or nothing to do with the medication they are taking,” she says.

What to know before taking GLP-1 medications

The medications are meant for people with higher BMIs

GLP-1 medications work by mimicking the hunger hormones that suppress appetite and promote satiety or a feeling of fullness.

“We have to remember that medications like Ozempic and Wegovy are meant for people who are over a BMI of 30 or 27 with one comorbidity,” says Batash. 

“These medications are frequently used off-label for people who are below a 27 BMI,” he adds. “Please remember that these medications got approved for weight loss only recently and we don’t know long-term side effects of these medications and dosages that are currently taken for weight loss,” he tells Healthline. 

Read the black box warning

Pepin says the safety warnings around the GLP-1 drugs are very explicit in the prescribing information. 

“A Black Box Warning, or the most serious type of warning that can be included in prescribing information, is common among these medications,” she says.

The FDA warning is to avoid these GLP-1 agonist medications if you have a history of or a family history of: 

  • medullary thyroid cancer because the GLP-1s may cause an increased risk of this type of cancer
  • pancreatitis, so it is recommended to avoid the drugs in people with a history of pancreatitis or at risk of pancreatitis

“Side effects of these medications can be pretty severe, and if your quality of life is affected, you should look for other methods that can help you lose weight,” says Batash. 

Not a sustainable long-term solution for weight loss

Batash says these medications are not a long-term solution for weight loss unless you are willing to commit to a lifetime of taking them. 

He also says you will need to consider the cost of medication use over a long period of time, asking yourself if it makes sense to spend large amounts of money to use medication that may not be medically necessary.

Pepin agrees. “People should consider the cost of the drugs because they are very expensive, particularly when taken for weight loss.”

“Very few, if any, insurance companies will pay for them,” she says.

Takeaways about suicide risk and Ozempic

“You should always be aware and be well-informed of all possible side effects of medications you are taking,” says Batash.

“It is important to be under medical supervision while taking any of the medications but especially ones that can affect your mental health,” he adds. 

“If you feel like you might be experiencing any of the side effects listed for medications that you are taking, it is important to inform your medical provider immediately.”

What to do if you experience suicidal thoughts while taking Ozempic or other GLP-1 drugs

There are a few more things to consider if you’re taking a GLP-1 medication and experiencing suicidal thinking. 

First, Pepin recommends the person call a suicide hotline or their therapist if they have one, immediately. 

If you or your loved one experiences suicidal thoughts, thoughts of self-harm, or extreme hopelessness, call the National Suicide Prevention Lifeline, for free and confidential support at 988.

Then, Pepin suggests that the person contact their provider as soon as possible and have a discussion regarding the continuation or discontinuation of the drug. 

“The provider can look at the individual’s health history and comorbidities to determine, if in their clinical judgment, it is prudent to continue the medication or not,” she says. “A risk-benefit analysis should also be done to aid in this situation,” says Pepin. 

Batash echoes this, noting that it’s important for any physician who is prescribing these medications to do a screening.

“A patient who has history of having mental health issues or experience suicidal thoughts should not be prescribed GLP-1 agonists for weight loss or diabetes and should be strongly cautioned about potential side effects,” says Batash. 

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